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KMID : 0942820080070020156
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Journal of Korean Brain Tumor Society
2008 Volume.7 No. 2 p.156 ~ p.160
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Met Tyrosine Kinase Receptor Expression and its Implication in Pituitary Adenomas
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Park Jung-Eon
Kim Hwa-Jung
Lee Bok-Soon
Lee Jae-Ho
Kim Se-Hyuk
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Abstract
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Objective: Met tyrosine kinase receptor is known as the receptor of hepatocyte growth factor(HGF) and met-HGF
signaling has been shown to affect a wide range of biological activities, including angiogenesis, cellular motility, growth,
and morphogenetic differentiation. However, little is known about its significance in pituitary adenomas(PAs). The goal
of this study is to verify Met-expression and its implication in PAs.
Materials & Methods: We collected fresh specimens from 29 PAs(11 functioning, 18 nonfunctioning) during surgery.
The samples were subjected to RT-PCR using human wild type Met(wtMet) primer to assess Met expression in RNA
level, and western blotting to assess its expression in protein level. We analyzed the relationship between Met expression
in mRNA or protein level and clinico-radiological factors.
Results: wtMet mRNA was expressed in 65.5%(19/29) and Met protein in 17.9%(5/28). Among 29 PAs, the incidence of wtMet mRNA expression was significantly higher in functioning PAs(90.9%) compared to nonfunctioning PAs
(50%). And patients’ age was significantly younger in wtMet expressed group(mean：42.8 years) compared to nonexpressed group(mean：55.1 years). The expression of wtMet mRNA or Met protein was not correlated with the other
clinico-radiological factors including the invasiveness.
Conclusion: Our results showed a positive relationship between wild type Met mRNA expression and endocrine activity.
We suggest that wild type Met(wtMet) mRNA expression might be one of the markers of functioning adenomas and its
clinical implication should be studied further.
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KEYWORD
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Met tyrosine kinase receptor, Functioning pituitary adenoma
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